R4,205.25 – R6,007.50
This antibody recognises an epitope within the corona virus receptor binding domain and binds a cross reactive epitope also present in the novel coronavirus. CR3022 works well in ELISA and western blot applications.
The CR3022 antibody we have produced is a well-known reagent whose sequence was identified by Yuan et al. from someone who recovered from the first SARS in around 2002. This antibody recognises an epitope within the corona virus receptor binding domain and binds a cross reactive epitope also present in the novel coronavirus. CR3022 works well in ELISA and western blot applications. It is available with a Human or Rabbit Fc region backbone and in 100ug or 1mg amounts.
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| Product name | Human Anti-SARS-CoV-2 RBD (CR3022) Antibody |
|---|---|
| Source | CR3022 variable regions fused to human IgG1: Heavy chain CR3022 (GenBank: DQ168569.1) – Human Heavy chain IgG1 (UniProtKB/Swiss-Prot: P01857.1) Light chain CR3022 (GenBank: DQ168570.1) – Human kappa chain (UniProtKB/Swiss-Prot: P01834.2) |
| Expression host | Nicotiana benthamiana plants |
| Tag | None |
| Description | Monoclonal antibody to COVID-19 & SARS-CoV S glycoprotein. Recombinantly expressed in Nicotiana benthamiana plants. Antibody was first described in: “Meulen et al. Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants PLoS Med. 2006 Jul; 3(7): e237 PMID:16796401” |
| Concentration | 2 mg/ml |
| Volume | Variable |
| Predicted molecular weight | Heavy chain: 52 kDa. Light chain: 27 kDa |
| Form | Liquid |
|---|---|
| Colour | Clear, slightly red/brown |
| Preparation instructions | None. Store immediately. |
| Storage | Short term: 2 – 4°C. Long term: -20°C |
| Storage buffer | pH 7.4. Preservative: none. 0.1M Phosphate Buffered saline (PBS) |
| Purification notes | This product was purified by Protein A affinity chromatography. |
| Purity | 90 – 95% as determined by SDS-PAGE (Fig. 1) |
| Conjugation notes | None |
| Clonality | Monoclonal |
| Isotype | Human IgG1 |
| Stability | Up to 1 year from delivery |
| General notes | If for any reason the product fails to give results, please contact our scientific support team for assistance. |
Figure 1: Coomassie stained SDS-PAGE gel showing purified CR3022. Lane 1: Molecular marker; Lane 2: Purified CR3022 antibody (10 ug loaded).
Notes: Two bands of approximately 55 kDa and 30 kDa can be observed corresponding to the heavy and light chains, respectively. The protein runs at a higher molecular weight due to glycosylation.
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Ndabeni, 7405
Cape Town, South Africa
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